/***********************************************
	Side Navbar
************************************************/
.mcs-investigator-studies-program>.container {
	margin-top: 1.4rem;
}

.side-nav-wrapper .tab-bar {
	display: flex;
	align-items: center;
	background-color: var(--color-gray);
	color: var(--color-blue);
	font-size: 13px;
}

.side-nav-wrapper .tab {
	padding: 0.2rem 0;
	text-align: center;
	width: 50%;
}

.side-nav-wrapper .tab:hover {
	color: var(--color-teal);
	background-color: var(--color-lighter-teal);
	cursor: pointer;
	transition: all 0.15s ease-in-out;
}

.side-nav-wrapper .tab.active {
	background-color: var(--color-teal);
	color: var(--color-white);
	cursor: default;
	font-weight: bold;
}

.side-nav-wrapper .side-nav-content {
	padding: 0.7rem;
}

.side-nav-wrapper .teal-outline {
	border: 2px solid var(--color-teal);
}

.side-nav-wrapper .inactive-aois-toggle-wrapper {
	border-bottom: 1px solid var(--color-muted-dark);
	padding-bottom: 0.5rem;
}

.side-nav-wrapper .toggle {
	cursor: pointer;
	/* display: inline-block; */
	display: flex;
	justify-content: space-between;
	align-items: center;
}

.side-nav-wrapper .toggle-switch {
	display: inline-block;
	background: #ccc;
	border-radius: 16px;
	width: 58px;
	height: 32px;
	position: relative;
	left: 9px;
	vertical-align: middle;
	transition: background 0.25s;
	transform: scale(0.70);
}

.side-nav-wrapper .toggle-switch:before,
.side-nav-wrapper .toggle-switch:after {
	content: "";
}

.side-nav-wrapper .toggle-switch:before {
	display: block;
	/* background: linear-gradient(to bottom, #fff 0%, #eee 100%); */
	background: var(--color-white);
	border-radius: 50%;
	/* box-shadow: 0 2px 2px 1px rgba(0, 0, 0, 0.25); */
	width: 24px;
	height: 24px;
	position: absolute;
	top: 4px;
	left: 4px;
	transition: left 0.25s;
}

.side-nav-wrapper .toggle:hover .toggle-switch:before {
	/* background: linear-gradient(to bottom, #fff 0%, #fff 100%); */
	background: var(--color-white);
	/* box-shadow: 0 2px 2px 1px rgba(0, 0, 0, 0.25); */
}

.side-nav-wrapper .toggle-checkbox:checked+.toggle-switch {
	background: var(--color-light-teal);
}

.side-nav-wrapper .toggle-checkbox:checked+.toggle-switch:before {
	left: 30px;
}

.side-nav-wrapper .toggle-checkbox {
	position: absolute;
	visibility: hidden;
	width: 0;
	height: 0;
}

.side-nav-wrapper .toggle-label {
	font-size: 12px;
	/* margin-right: .4rem; */
}

.side-nav-wrapper .aois-outline-wrapper {
	/* padding-top: 1rem; */
}

.side-nav-wrapper {
	position: sticky;
	top: 1rem;
	margin-bottom: 2.1rem;
	margin-right: 0.3rem;
}

.side-frame {
	padding: 0;
}

.side-frame .therapeutic-areas ul {
	margin-left: 0;
	padding-left: 0;
}

.side-nav-wrapper .therapeutic-areas li {
	list-style: none;
}

.side-nav-wrapper .therapeutic-areas li.primary {
	color: var(--color-teal);
	font-size: 14px;
	font-weight: bold;
}

.side-nav-wrapper .therapeutic-areas li.primary:not(:first-child) {
	padding-top: 1rem;
}

.side-nav-wrapper a.collapse-toggle {
	text-decoration: none;
	transition: color 0.2s ease-out;
}

.side-nav-wrapper a.collapse-toggle:hover {
	color: var(--color-light-teal);
}

.side-nav-wrapper .collapse-toggle .expand-icon {
	margin-left: 0.5rem;
}

.side-nav-wrapper .collapse-toggle .expand-icon svg {
	position: relative;
	top: -1px;
	transition: transform 0.4s ease-out;
}

.side-nav-wrapper .collapse-toggle[aria-expanded="false"] .expand-icon svg {
	transform: rotate(-90deg);
}

.side-nav-wrapper .therapeutic-areas ul.secondary li {
	color: var(--color-blue);
	font-size: 12px;
	font-weight: bold;
}

.side-nav-wrapper ul.therapeutic-areas {
	padding-left: 0.3rem;
}

.side-nav-wrapper .therapeutic-areas ul.tertiary li {
	border-left: 0.5px solid var(--color-gray-30);
	color: var(--color-blue);
	font-size: 12px;
	font-weight: normal;
	margin-top: 0;
	margin-left: 0.2rem;
	padding-left: 1.4rem;
	text-indent: -0.7rem;
	text-wrap: balance;
	transition: all 0.2s ease-out;
}

.side-nav-wrapper .therapeutic-areas ul.tertiary li.inactive:after {
	color: var(--color-muted-dark);
	content: " (Inactive)"
}

.side-nav-wrapper .therapeutic-areas li.primary.inactive:after,
.side-nav-wrapper .therapeutic-areas ul.secondary li.inactive:after {
	color: var(--color-muted-dark);
	content: " (Inactive)"
}

.side-nav-wrapper .therapeutic-areas ul.flat.tertiary li {
	border-left: none;
	margin-left: 0;
	padding-left: 1.4rem;
	padding-right: .6rem;
}

.side-nav-wrapper .therapeutic-areas ul.flat.tertiary li:not(:last-child) {
	margin-bottom: 0.4rem;
}

.side-nav-wrapper .therapeutic-areas ul.tertiary li:hover {
	color: var(--color-blue);
	cursor: pointer;
	font-weight: bold;
}

.side-nav-wrapper .therapeutic-areas ul.tertiary li.active {
	background-color: var(--color-blue);
	color: var(--color-white);
	font-weight: bold;
	width: 98%;
}


/*********************************************************************
	AOI Areas of Interest & Submission Materials Page Main Content Area
**********************************************************************/
.main-frame .page-header-wrapper {
	background: var(--color-teal);
	padding: 1.4rem 1.2rem;
}

.main-frame .page-header-wrapper h1 {
	color: var(--color-white);
	font-size: 26px;
	font-style: normal;
	font-weight: 300;
	margin: 0;
}

.main-frame .intro {
	font-size: 0.875rem;
	line-height: 1.57;
	padding: 1rem 1rem 0 1rem;
}

.main-frame h2 {
	color: var(--color-teal);
	display: none;
	font-size: 1.5rem;
	font-weight: bold;
	padding: 1rem 1rem 0 1rem;
	text-wrap: pretty;
}

.main-frame .subtype-headline {
	display: flex;
	justify-content: start;
}

.main-frame .subtype-wrapper {
	display: flex;
	flex-wrap: wrap;
	justify-content: center;
}

.main-frame .subtype-wrapper button {
	font-size: 0.75rem;
}

.main-frame .subtype-wrapper button.aoi-subtype {
	margin-top: .3rem;
	margin-right: .3rem;
	min-width: 16rem;
	min-height: 4.3rem;
	max-width: 13rem;
	padding: 0.4rem 0.5rem;
}

.main-frame .subtype-wrapper button.aoi-subtype.active {
	background-color: var(--color-teal);
	color: var(--color-white);
}

.main-frame .subtype-wrapper .right-chevron-wrapper {
	position: relative;
	margin-left: .5rem;
	top: -1px;
}

.main-frame .subtype-wrapper svg.right-chevron {
	/* transform: scale(1.5); */
}

.main-frame .aoi-content-wrapper {
	border: 2px solid var(--color-gray-20);
	border-radius: 6px;
	/* font-size: 0.875rem; */
	padding: 1rem 1rem;
	margin-top: 1rem;
	margin-bottom: 3rem;
}

.main-frame .aoi-content-wrapper .cms-content a {
	text-decoration: none;
}

.main-frame .aoi-content-wrapper .cms-content a:hover {
	text-decoration: underline;
}

.main-frame ul,
.main-frame .cms-content ul,
.mcs-cms-content ul {
	margin-left: 0;
	padding-left: 1.1rem;
}

.main-frame ul>li,
.main-frame .cms-content ul>li,
.mcs-cms-content ul>li {
	list-style: unset;
	text-indent: 0rem;
}

.main-frame ul>li::marker,
.main-frame .cms-content ul>li::marker,
.mcs-cms-content ul>li::marker {
	/* The "::marker" pseudo-element doesn't allow position:relative by spec,
   * so we can't adjust the vertical position of the standard bullet symbols.
	 * Also, we're usng "em" intentionally (not "rem") to scale relative to self. */
	font-size: 0.85em;
}

.main-frame ul.hyphen-list > li {
  list-style-type: "– ";
	margin-left: -5px;
	padding-left: 5px;
}

.main-frame ul.hyphen-list li ul li ul li ul li {
	list-style: disc;
}

.main-frame ol {
	list-style-type: decimal;
	padding-left: 1rem;
	/* margin-top: 0.5rem; */
}

.main-frame ol ol {
	list-style-type: lower-alpha;
}

.main-frame ul li:not(:first-child),
.main-frame ol li:not(:first-child)
{
	margin-top: var(--list-spacing);
}

.main-frame .subtype-headline-wrapper {
	display: flex;
	align-items: center;
	justify-content: start;
	padding-top: 0.2rem;
	padding-bottom: 0.8rem;
}

.main-frame .subtype-headline-wrapper .icon-wrapper {
	padding-right: 0.6rem;
}

.main-frame .subtype-headline-wrapper h3 {
	font-size: 1rem;
	font-weight: bold;
}

.aois-submats-page-wrapper .wizard-wrapper {
	display: block;
}

.aois-submats-page-wrapper .mcs-investigator-studies-program .main-frame .aoi-content-wrapper .cms-content h3,
.aois-submats-page-wrapper .mcs-investigator-studies-program .main-frame .aoi-content-wrapper .cms-content h4,
.main-frame .cms-title
{
	display: inline-block;
	font-size: 1rem;
	font-weight: bold;
	margin-bottom: 0.5rem;
	padding-top: 0.2rem;
}

.main-frame light-teal-panel {
	background-color: #E2F5F0;
	display: block;
	margin: 1.8rem 0;
	padding: 1.1rem 1.5rem 1.6rem;
}

.main-frame light-teal-panel ul {
	margin-bottom: 0;
}

.main-frame light-teal-panel ul li,
.main-frame light-teal-panel ol li
{
	padding-left: 0rem;
	text-wrap: pretty;
}
.main-frame .cms-content light-teal-panel ol li ul li {
	list-style: disc;
}

.aois-submats-page-wrapper .mcs-investigator-studies-program .main-frame .aoi-content-wrapper .cms-content light-teal-panel h3,
.aois-submats-page-wrapper .mcs-investigator-studies-program .main-frame .aoi-content-wrapper .cms-content light-teal-panel h4,
.main-frame light-teal-panel .cms-title
{
	padding-top: 0.8rem;
}

.main-frame .end-matter {
	padding-top: .4rem;
}
.main-frame figure.table {
	/* Allows scrollbar on mobile portrait view
*  * for deadlines table */
	overflow-x: auto;
}
.main-frame table {
	border: 1px solid var(--color-light-gray);
	margin-bottom: 1.8rem;
	width: 100%;
}
.main-frame table tr td {
	border-top: 1px solid var(--color-light-gray);
	border-right: 1px solid var(--color-light-gray);
}
.main-frame table tr th,
.main-frame table tr td {
	font-size: 0.875rem;
	padding: 0.3rem 1rem;
}
.main-frame table tr th:first-child {
	/* padding-left: 1rem; */
}
.main-frame main tr,
.main-frame main tr:nth-of-type(even),
.main-frame main tr:nth-of-type(odd)
{
	background-color: var(--color-white);
}

.main-frame .alert-icon-wrapper {
	border: 1px solid rgba(175, 24, 32, .32);
	margin-top: 1.7rem;
	padding: 1.2rem 1.5rem;
}

.main-frame .alert-text {
	padding-top: 0.5rem;
}

.main-frame .submats-wrapper {
	background-color: rgba(231, 232, 234, 0.54);
	padding: 1.3rem 1.3rem;
	margin-top: 1.5rem;
}

.main-frame .submats-wrapper h5 {
	font-weight: 300;
	/* font-size: 0.875rem; 14px Light seems very small compared to body text */
	font-size: 1rem;
	margin-bottom: 0.2rem;
}

.main-frame .submats-wrapper h5 > p {
	/* Fix extra padding for forced <p> inserted by CKEditor rich text editor by CMS */
	margin-bottom: 0;
}

.main-frame .submats-title-wrapper {
	display: flex;
	align-items: center;
	justify-content: start;
	border-bottom: 0.5px solid black;
	padding-top: 0.2rem;
	padding-bottom: 0.9rem;
}

.main-frame .submats-title-wrapper .icon-wrapper {
	padding-right: 0.6rem;
}

.main-frame .submats-title-wrapper h3 {
	font-size: 1.125rem;
	font-weight: 700;
	margin-bottom: 0.2rem;
}

.main-frame .submats-wrapper section[class*="-question-wrapper"] {
	padding-top: 1.2rem;
}

.main-frame .submats-instructions-wrapper {
	padding-top: 1.5rem;
}

.main-frame .instructions-title-wrapper {
	background-color: var(--color-white);
	padding: 1rem 1rem 0 1rem;
}

.main-frame .instructions-title-wrapper .title {
	font-size: 1.125rem;
	font-weight: bold;
	border-bottom: 1px solid var(--color-gray-30);
	padding-bottom: 0.7rem;
}

section.submats-instructions-wrapper .step-title {
	font-size: 1.125rem;
}

.submats-wrapper .mcs-submissions-results-steps:nth-last-child(2) .step-content {
	padding-bottom: 0.6rem;
}

.main-frame .submats-wrapper .access-download-btn-inner {
	font-size: 0.75rem;
}

.main-frame .submats-wrapper .mcs-submissions-materials-step a.btn {
	font-size: 0.875rem;
}

.main-frame .step-content-less-padding {
	padding-bottom: 1rem;
}

.main-frame .submats-wrapper .non-us-end-content {
	background-color: #fff;
	font-size: 1.125rem;
	font-weight: bold;
	padding: 1rem;
	padding-top: 0;
}

/* Info icon inline with text */
.mcs-form-label {
	display: block;
}

.mcs-form-label p {
	display: inline-block;
	margin: 0;
}

/* Simple data-attribute tooltip (CKEditor-friendly) - works with dynamically loaded content */
.info-icon[data-tooltip] {
	position: relative;
	display: inline-flex;
	align-items: center;
	justify-content: center;
	width: 20px;
	height: 20px;
	border-radius: 50%;
	background-color: transparent;
	border: 2px solid #6c757d;
	color: #6c757d;
	font-size: 0.75rem;
	font-weight: bold;
	font-style: normal;
	cursor: help;
	transition: all 0.2s ease;
	margin-left: 0.25rem;
	vertical-align: middle;
}

.info-icon[data-tooltip]:hover {
	background-color: #5450e4;
	border-color: #5450e4;
	color: white;
}

.info-icon[data-tooltip]::after {
	content: attr(data-tooltip);
	visibility: hidden;
	opacity: 0;
	position: absolute;
	left: 30px;
	top: 50%;
	transform: translateY(-50%);
	background-color: #5450e4;
	color: white;
	padding: 1rem 1.25rem;
	border-radius: 8px;
	width: 320px;
	box-shadow: 0 4px 12px rgba(0, 0, 0, 0.15);
	z-index: 1000;
	transition: opacity 0.3s ease, visibility 0.3s ease;
	font-size: 0.875rem;
	line-height: 1.5;
	white-space: normal;
	pointer-events: none;
}

.info-icon[data-tooltip]::before {
	content: '';
	visibility: hidden;
	opacity: 0;
	position: absolute;
	left: 22px;
	top: 50%;
	transform: translateY(-50%);
	width: 0;
	height: 0;
	border-top: 8px solid transparent;
	border-bottom: 8px solid transparent;
	border-right: 8px solid #5450e4;
	z-index: 1001;
	transition: opacity 0.3s ease, visibility 0.3s ease;
}

/* Mobile responsive */
@media (max-width: 768px) {
	.info-icon[data-tooltip]::after {
		left: auto;
		right: 0;
		width: 280px;
		top: 30px;
		transform: none;
	}

	.info-icon[data-tooltip]::before {
		left: 10px;
		top: 22px;
		transform: none;
		border-left: 8px solid transparent;
		border-right: 8px solid transparent;
		border-bottom: 8px solid #5450e4;
		border-top: none;
		border-right: none;
	}
}

.form-check-wrapper {
	position: relative;
}

.mcs-form-label {
	position: relative;
	display: inline-block;
}

/* Mobile responsive */
@media (max-width: 768px) {
	.custom-tooltip {
		left: auto;
		right: 0;
		width: 280px;
		top: 30px;
		transform: none;
	}

	.custom-tooltip::before {
		left: 10px;
		top: -8px;
		transform: none;
		border-left: 8px solid transparent;
		border-right: 8px solid transparent;
		border-bottom: 8px solid #5450e4;
		border-top: none;
	}
}

/* Alternative: Simple data-attribute tooltip (CKEditor-friendly) */
.info-icon[data-tooltip] {
	position: relative;
	display: inline-flex;
	align-items: center;
	justify-content: center;
	width: 20px;
	height: 20px;
	border-radius: 50%;
	background-color: transparent;
	border: 2px solid #6c757d;
	color: #6c757d;
	font-size: 0.75rem;
	font-weight: normal;
	font-style: normal;
	cursor: help;
	text-wrap: pretty;
	transition: all 0.2s ease;
	margin-left: 0.25rem;
	vertical-align: middle;
}

.info-icon[data-tooltip]:hover {
	background-color: #5450e4;
	border-color: #5450e4;
	color: white;
}

.info-icon[data-tooltip]::after {
	content: attr(data-tooltip);
	visibility: hidden;
	opacity: 0;
	position: absolute;
	left: 30px;
	top: 50%;
	/* transform: translateY(-50%); */
	transform: translate(-59%, -113%);
	background-color: #5450e4;
	color: white;
	padding: 1rem 1.25rem;
	border-radius: 8px;
	width: 320px;
	box-shadow: 0 4px 12px rgba(0, 0, 0, 0.15);
	z-index: 1000;
	transition: opacity 0.3s ease, visibility 0.3s ease;
	font-size: 0.875rem;
	line-height: 1.7;
	white-space: normal;
	pointer-events: none;
}

.info-icon[data-tooltip]::before {
	content: '';
	visibility: hidden;
	opacity: 0;
	position: absolute;
	left: 22px;
	top: 50%;
	transform: translateY(-50%);
	width: 0;
	height: 0;
	border-top: 8px solid transparent;
	border-bottom: 8px solid transparent;
	border-right: 8px solid #5450e4;
	z-index: 1001;
	transition: opacity 0.3s ease, visibility 0.3s ease;
}

/* Desktop: show on hover */
@media (hover: hover) and (pointer: fine) {
	.info-icon[data-tooltip]:hover::after {
	/* .info-icon[data-tooltip]:hover::before { */
		visibility: visible;
		opacity: 1;
	}
}

/* Mobile: show only when active class is present */
@media (hover: none) and (pointer: coarse) {
	.info-icon[data-tooltip].info-icon-active::after {
	/* .info-icon[data-tooltip].info-icon-active::before { */
		visibility: visible;
		opacity: 1;
	}
}

/* Fallback for all devices - active class always shows tooltip */
.info-icon[data-tooltip].info-icon-active::after {
/* .info-icon[data-tooltip].info-icon-active::before { */
	visibility: visible;
	opacity: 1;
}

/* For tablet above phone but less than desktop */
@media (max-width: 1199px) {
	/* For left sidebar */
  .mcs-submission-options-column:first-child {
    flex: 0 0 11rem;
  }
  .mcs-columns-separator {
    top: -0.6rem;
    margin: -0.5rem 0;
  }
  .mcs-submissions-materials-step .step-title {
    padding-top: 2rem;
  }
}

/* For phone and tablet */
@media (max-width: 768px) {
	.side-nav-wrapper .tab-bar {
		/* font-size: 1rem; */
		font-size: 0.875rem;
	}
	.side-nav-wrapper .toggle-label {
		font-size: 1rem;
	}
	.side-nav-wrapper .therapeutic-areas li.primary {
		font-size: 1rem;
	}
	.side-nav-wrapper .collapse-toggle .expand-icon svg {
		scale: 1.3;
	}
	.side-nav-wrapper .therapeutic-areas ul.secondary li {
		font-size: 1rem;
	}
	.side-nav-wrapper .therapeutic-areas ul.tertiary li {
		font-size: 1rem;
		padding-top: 0.1rem;
		padding-bottom: 0.1rem;
	}

	/* For phone tall orientation */
@media (max-width: 576px) {
		.mcs-wizard-layout .container {
			margin: 0;
			padding: 0;
		}
		.mcs-wizard-layout .container .row {
			margin: 0;
			padding: 0;
		}
		.side-frame {
			padding: 0;
		}
		.side-nav-wrapper {
			margin: 0;
		}
		.side-nav-wrapper .toggle {
			padding-right: 0.6rem;
		}
		.main-frame {
			margin: 0;
			padding: 0;
		}
}

	/* Download submission materials section */
  .mcs-submission-options-column:first-child {
    flex: 0 0 11rem;
  }
  .mcs-columns-separator {
    top: -0.6rem;
    margin: 0 0;
	}
	.mcs-submission-options-column .mcs-submission-download-option .access-download-btn .btn-mcs {
		width: 106%;
	}
}